Abstract
Introduction: The influence of static magnetic fields on living organisms has been the topic of considerable interest for many years. However, the exact mechanism of static magnetic fields’ action is still unclear. This research was performed to evaluate possible relationship between static magnetic fields and cancer treatment and also determine the possible effects of co-treatment with anticancer drugs in normal and cancerous cells.
Methods: The effects of 10 mT static magnetic field on cell death (sub-G1 and apoptosis/necrosis) were investigated using flow cytometric methods. This study was performed in the presence and absence of cisplatin as an anticancer agent in HeLa cell line as cancerous and Hu02 as normal cell type.
Results: Static magnetic fields’ exposure causes an increase in cell death in HeLa cell line (at both times) and Hu02 at 24 h after treatment. Moreover, co-treatment of these fields and cisplatin led to an enhancement in cell death at 24 h via necrosis, early and late apoptosis, and a decrease in cell death in the first 48 h in both cell types.
Conclusion: Despite the fact that 10 mT intensity of static magnetic field is not a high value, it was able to change cell function and structure, which in turn leads to change in apoptosis rate. The data presented in this literature, may indicate that static magnetic field can decrease the cell death; but more investigations are needed to find the exact related mechanisms.
Methods: The effects of 10 mT static magnetic field on cell death (sub-G1 and apoptosis/necrosis) were investigated using flow cytometric methods. This study was performed in the presence and absence of cisplatin as an anticancer agent in HeLa cell line as cancerous and Hu02 as normal cell type.
Results: Static magnetic fields’ exposure causes an increase in cell death in HeLa cell line (at both times) and Hu02 at 24 h after treatment. Moreover, co-treatment of these fields and cisplatin led to an enhancement in cell death at 24 h via necrosis, early and late apoptosis, and a decrease in cell death in the first 48 h in both cell types.
Conclusion: Despite the fact that 10 mT intensity of static magnetic field is not a high value, it was able to change cell function and structure, which in turn leads to change in apoptosis rate. The data presented in this literature, may indicate that static magnetic field can decrease the cell death; but more investigations are needed to find the exact related mechanisms.
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