Effect of low-frequency rotary magnetic fields on advanced gastric cancer: Survival and palliation of general symptoms

Objective: The tumor inhibition by magnetic fields (MFs) has been reported in many in vivo and in vitro studies, while clinical trials have been rare. This report aimed to evaluate the improvement of survival and general symptoms in advanced cancer patients treated with MFs.
Subjects and Methods: In this study, we investigated 21 patients with advanced gastric cancer (AGC) treated with 420 r/min, 0.4-T low-frequency rotary MFs. The treatment area encompassed the primary tumor sites, metastatic sites, and metastatic lymph nodes. In addition, the patients were treated 2 h per day, 5 days per week for 6–12 weeks. The toxicity pilot human study was approved by the competent ethical committee. Toxicity and side effects were assessed according to the WHO criteria. The changes of general symptoms were analyzed during low-frequency rotary MFs treatment and 2 weeks after the end of therapy. Electrocardiogram, chest X-ray, physical examination, blood cell count and complete blood chemistry, biochemical, and kidney function tests were performed before and after the end of the treatment. All 21 patients were followed up by outpatient service or telephone interview.
Results: Our results demonstrated that low-frequency rotary MFs improved abdominal pain in 9/21 (42.9%), nausea/vomiting in 4/21 (19.0%), weight loss in 11/21 (52.4%), ongoing blood loss in 2/21 (9.5%), physical strength in 5/21 (23.8%), and sleep quality in 4/21 (19.0%) patients. No severe toxicity and side effect were observed in our trial. The median survival time was 8.0 months (95% confidence interval, 5.190–10.810). The 1-year survival rate was 25.8%.
Conclusion: Low-frequency rotary MFs may prolong survival and improve general symptom of AGC patients, as an effective, well-tolerated, and safe treatment choice.
http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=4;spage=815;epage=819;aulast=Chen

A novel biophysical quantum algorithm predicts super-conductive properties in animate and inanimate systems

This paper addresses the question whether superconductive phenomena in superconductive materials and in life systems have common physical grounds. An extensive literature survey was performed with regard to intrinsic energy gap frequencies reported on a range of superconductor materials as measured by different spectroscopic technologies. The registered frequencies were plotted on an acoustic scale and compared with earlier detected EM frequency patterns revealed in various life systems. A meta-analysis showed that the particular wave frequency patterns in superconducting materials have discrete coherent frequency bands and are very much in line with those found in biological systems. We hypothesize that the revealed individual frequencies either alone or in combination provide a means to select or identify materials that exhibit superconductive properties at elevated critical temperature ranges. We propose that the spectral energy gaps of superconducting materials can be positioned at the pointer states of a pattern of coherent frequencies, and can be described by an acoustic algorithm, coined by us the GM-biophysical principle. High Temperature Superconductors (HTSC's) show patterns of frequencies, in which frequency ratios of 2:3 (third harmonic) are incorporated in ratios of 1:2 (fundamental frequency). We propose to apply semi-conductive smectites (phyllosilicates), studied in detail by us earlier, that radiate GM-like EMF frequencies, in combination with HTC superconductor materials, to further improve superconductive properties as a modality of intrinsic quantum lasing. Our observations highlight a potential quantum bridge between superconducting properties in physics and biology.
https://www.researchgate.net/publication/331902977_A_novel_biophysical_quantum_algorithm_predicts_super-conductive_properties_in_animate_and_inanimate_systems

Quantum sensing method measures minuscule magnetic fields

Once perfected, this technique may be useful for this field magnetic fields for cancer treatment:

"A new way of measuring atomic-scale magnetic fields with great precision, not only up and down but sideways as well, has been developed by researchers at MIT. The new tool could be useful in applications as diverse as mapping the electrical impulses inside a firing neuron, characterizing new magnetic materials, and probing exotic quantum physical phenomena."

…

"Unlike some other systems that require extremely low temperatures to operate, this new magnetic sensor system can work well at ordinary room temperature, Liu says, making it feasible to test biological samples without damaging them."

https://www.sciencedaily.com/releases/2019/03/190315115929.htm

Electromagnetic Field Therapy for Dogs With Spinal Injuries

Spinal surgery can involve a painful recovery process – whether you’re a human or a dog. But what if a noninvasive treatment utilizing a pulsed electromagnetic field (PEMF) could improve pain, reduce inflammation and possibly aid motor recovery? A recent small clinical trial at NC State’s College of Veterinary Medicine set out to see whether this was the case – and some of the results were promising.
https://news.ncsu.edu/2018/03/olby-emf/

Use of ultrasound with magnetic field for enhanced in vitro drug delivery in colon cancer treatment

Drug delivery systems (DDSs) have been developed to target tumor cells by releasing active biomolecules at the specific site of infection, thus eliminating the side effects of anticancer drugs. However, DDSs are generally limited by high drug dosage, biobarriers, poor target recognition, etc. To address these deficiencies, we propose a new noninvasive method consisting of exposing the cancer cells to a combination of low-intensity pulsed ultrasound (LIPUS) and static magnetic field (SMF). This combined treatment found to negatively regulate colon cancer cell (HCT116) activities in vitro by altering their cell membrane potential and permeability thus increased the DDS efficacy by 40%. The treated cancer cell membrane became hyperpolarized leading to cancer cell death. The combination treatment (LIPUS + SMF) restricted the cancer cell proliferation to 16 and 5% in the presence of bare anticancer drug and DDS, respectively, in 72 h, which is almost 40% higher than that observed without the treatment. The acceleration of cancer cellular inhibition was confirmed by the significant increase in the apoptosis of the cell exposed to the LIPUS + SMF treatment. The observed improvement is believed to be due to changes in the cell membrane stability/permeability as a result of mechanical (20–22 kPa) and electrical (19–23 µV/cm) stimuli generated during the LIPUS + SMF treatment.

Developmental bioelectricity

The ability to control pattern formation is critical for the both the embryonic development of complex structures as well as for the regeneration/repair of damaged or missing tissues and organs. In addition to chemical gradients and gene regulatory networks, endogenous ion flows are key regulators of cell behavior. Not only do bioelectric cues provide information needed for the initial development of structures, they also enable the robust restoration of normal pattern after injury. In order to expand our basic understanding of morphogenetic processes responsible for the repair of complex anatomy, we need to identify the roles of endogenous voltage gradients, ion flows, and electric fields. In complement to the current focus on molecular genetics, decoding the information transduced by bioelectric cues enhances our knowledge of the dynamic control of growth and pattern formation. Recent advances in science and technology place us in an exciting time to elucidate the interplay between molecular-genetic inputs and important biophysical cues that direct the creation of tissues and organs. Moving forward, these new insights enable additional approaches to direct cell behavior and may result in profound advances in augmentation of regenerative capacity.
https://www.researchgate.net/publication/322057561_Bioelectric_signaling_in_regeneration_Mechanisms_of_ionic_controls_of_growth_and_form

Electromagnetic field causes pleiotropic effects in a commercial medicine for nephritis treatment

A polysaccharide of Irpex lacteus, a white‐rot fungus with lignocellulose‐degrading activities, has been used as a commercial medicine for nephritis treatment. Previously, a low‐intensity electromagnetic field (LI‐EMF) was found to increase the biomass and polysaccharide content of Irpex lacteus and induce twists on the cell surface. In this study, RNA‐sequencing (RNA‐seq) technology was used to analyze the underlying mechanism of LI‐EMF's influence on Irpex lacteus. We identified 3268, 1377, and 941 differentially expressed genes (DEGs) in the LI‐EMF‐treated samples at recovery times of 0 h, 3 h, and 6 h, respectively, indicating a significant decline in the influence of the LI‐EMF treatment on Irpex lacteus with the passage of recovery time. Moreover, 30 upregulated and 14 downregulated DEGs overlapped in the LI‐EMF‐treated samples at the recovery times of 0 h, 3 h, and 6 h, implying the important lasting effects of LI‐EMF. The reliability of the RNA‐seq data were validated by quantitative real‐time PCR (qRT‐PCR). The DEGs related to transcription factors, cell proliferation, cell wall, membrane components, amino acid biosynthesis and metabolism, and polysaccharide biosynthesis and metabolism were significantly enriched in the LI‐EMF‐treated samples. The experiments confirmed that the LI‐EMF treatment significantly increased the content of amino acids with a considerable increase in the content of essential amino acids. Therefore, the global gene expression changes explained the pleiotropic effects of Irpex lacteus induced by the LI‐EMF treatment. These findings provide the requisite data for the appropriate design and application of LI‐EMF in the fermentation of microorganisms to increase production. 
https://onlinelibrary.wiley.com/doi/full/10.1002/bem.22171