End-Stage Recurrent Glioblastoma Treated With a New Noninvasive Non-Contact Oncomagnetic Device

 The Oncomagnetic device consists of 3 oncoscillators securely attached to an acrylonitrile butadiene styrene helmet and connected to a microprocessor-based electronic controller operated by a rechargeable battery (Figure 1). Further details regarding the device are given in the Supplementary Appendix. Based on a finite element model-based calculation of the spread of the field and the size and magnetization of the rotated diametrically magnetized neodymium magnets, we estimated that the combined effective field (at least 1 mT in strength) of the 3 oncoscillators covered the entire brain, including the upper part of the brain stem.

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“CELEX” hypothesis of cancer metastasis

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It was back in the mid-1990s that Djamgoz first developed what he would later call the cellular excitability or “CELEX” the “CELEX” hypothesis of cancer metastasis. He identified voltage-gated sodium ion channels in many types of epithelial cancer cells that did not belong, and which led to cancer cells producing action potentials as if they were neurons or cardiomyocytes.

“These are normally inert tissues in your gut or skin,” Djamgoz pointed out. “They become hyperactive, excitable, invasive, antisocial, and it is this electrical excitability that drives the cancer cells into an invasive mode.”

The electrical excitability of cancer cells escaped notice for years because traditional methods of measurement, patch clamp, or microelectrode recordings, lacked the sensitivity to capture the signals.

“Instead of poking the cells with micro-electrodes, we want to plate the cells in a petri-dish with these gold microelectrode arrays on the bottom,” Djamgoz continued. “They are now sitting on these electrodes and buzzing with action potentials!”

Not only do cancer cells become unexpected generators of bioelectricity, but they also communicate with the nervous system, seemingly feeding off of it. In a paper published June 2020 in Biochimica et Biophysica Acta — Reviews on Cancer,  Djamgoz showed that sympathetic nervous system stimulation seems to drive the early stages of cancer proliferation, while parasympathetic input drives invasiveness and metastasis.

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Magnetic therapy enhances chemo treatment of breast cancer

 The non-invasive and painless treatment has the potential to lower adverse side effects of chemotherapy, which are sometimes so severe that patients need to terminate treatment early or doctors have to reduce the chemo dosage, and this could worsen their disease. 

“Our magnetic technology stimulates cellular oxygen respiration to produce energy,” said team leader Associate Professor Alfredo Franco-Obregón. “In certain cancers with elevated respiratory rates — such as breast tumours — the magnetic pulses cause the cancer cells to ‘hyperventilate’ and die. Fortunately, the healthy tissues near the cancer are able to tolerate the increased respiratory rate, without ill consequences. Therefore, the OncoFTX System is more selective for cancer than conventional chemotherapy or radiotherapy. Importantly, this therapy is localised, non-invasive and painless.

Each session of magnetic therapy involves exposing a breast tumour to a pulsed magnetic field at a strength of 3 millitesla, for one hour. This field amplitude is about 50 times greater than the amplitude of the Earth’s magnetic field, but 1000 times smaller than conventional magnetic resonance imaging. Safety and efficacy trials will determine the best treatment frequency for breast cancer patients.

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Tumors partially destroyed with sound don't come back

 Noninvasive sound technology breaks down liver tumors in rats, kills cancer cells and spurs the immune system to prevent further spread -- an advance that could lead to improved cancer outcomes in humans.

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