Wednesday, April 24, 2019

FDA Approves New Treatment For ADHD Using Electrical Shocks To The Forehead

NEW YORK (CBSNewYork) – There’s an exciting breakthrough for the treatment of ADHD, and it does not involve drugs.
It’s the first FDA-approved medical device for the condition and CBS2’s Dr. Max Gomez reports that it works by stimulating nerves in the forehead.
https://newyork.cbslocal.com/2019/04/23/adhd-treatment-electrical-shocks/

Tuesday, April 23, 2019

On The Existence of The DNA Resonance Code and Its Possible Mechanistic Connection to The Neural Code

A possible role of DNA sequence-specific electromagnetic resonances in the formation of the morphogenic field is discussed. It is proposed that the morphogenic field is formed by resonant oscillations of delocalized electron and proton clouds in the base stack of the DNA. Models are proposed for DNA sequence-dependence of possible electromagnetic resonance patterns. It is proposed that genomic repeats act as universal resonators providing the bidirectional communication between the chromatin structure and the morphogenic field. It is proposed that genomic repeats participate in two major functions - the morphogenic function and the brain function. It is proposed that microtubules mediate the resonance communication between the action potential in axons and genomic repeats in the nucleus. The existence of an algorithm is proposed responsible for the conversion of genomic information into the shape of the body. Such an algorithm is named the DNA resonance code. It is proposed that the DNA resonance code can be deciphered by targeted efforts in biophysics, spectroscopy, molecular modeling, and experimental genomics. A possible resonance interaction between the DNA of neurons and neuronal firing is discussed and it is suggested that deciphering the DNA resonance code may be of help to deciphering the neuronal coding in the brain. It is suggested that the deciphering of the DNA resonance code would benefit medical applications related to morphogenesis and brain function
https://www.researchgate.net/publication/332438253_On_The_Existence_of_The_DNA_Resonance_Code_and_Its_Possible_Mechanistic_Connection_to_The_Neural_Code

Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice

Moderate intensity low frequency rotating magnetic field (LF-RMF) has been shown to inhibit melanoma, liver and lung cancer growth in mice. However, its effects on other types of cancers have not been investigated in vivo. Here, we show that 0–0.15T moderate intensity 4.2 Hz LF-RMF can inhibit tumor growth in mice bearing MDA-MB231 and MCF7 human breast cancer cells by over 30%. In contrast, the human gastrointestinal stromal tumor GIST-T1 growth was not inhibited by LF-RMF. In all RMF treatments, there were no apparent adverse effects on mice organs, body weight or water/food consumptions. However, the alanine aminotransferase (ALT) level was decreased in LF-RMF-treated mice bearing MCF7 and GIST-T1 cells, which indicated alleviated liver damage. Therefore, our study shows that moderate intensity LF-RMF might be a safe physical method that has clinical potentials to be used to inhibit breast cancer growth in the future.
https://www.researchgate.net/publication/327213612_Moderate_intensity_low_frequency_rotating_magnetic_field_inhibits_breast_cancer_growth_in_mice

Sunday, April 21, 2019

Intercellular Connectivity and Multicellular Bioelectric Oscillations in Nonexcitable Cells: A Biophysical Model

Bioelectricity is emerging as a crucial mechanism for signal transmission and processing from the single-cell level to multicellular domains. We explore theoretically the oscillatory dynamics that result from the coupling between the genetic and bioelectric descriptions of nonexcitable cells in multicellular ensembles, connecting the genetic prepatterns defined over the ensemble with the resulting spatio-temporal map of cell potentials. These prepatterns assume the existence of a small patch in the ensemble with locally low values of the genetic rate constants that produce a specific ion channel protein whose conductance promotes the cell-polarized state (inward-rectifying channel). In this way, the short-range interactions of the cells within the patch favor the depolarized membrane potential state, whereas the long-range interaction of the patch with the rest of the ensemble promotes the polarized state. The coupling between the local and long-range bioelectric signals allows a binary control of the patch membrane potentials, and alternating cell polarization and depolarization states can be maintained for optimal windows of the number of cells and the intercellular connectivity in the patch. The oscillatory phenomena emerge when the feedback between the single-cell bioelectric and genetic dynamics is coupled at the multicellular level. In this way, the intercellular connectivity acts as a regulatory mechanism for the bioelectrical oscillations. The simulation results are qualitatively discussed in the context of recent experimental studies.
https://www.researchgate.net/publication/328397452_Intercellular_Connectivity_and_Multicellular_Bioelectric_Oscillations_in_Nonexcitable_Cells_A_Biophysical_Model

Thursday, April 11, 2019

Human Biofield Therapy and the Growth of Mouse Lung Carcinoma

This is so strange, I wanted to disregard it, but cannot:

"Biofield therapies have gained popularity and are being explored as possible treatments for cancer. In some cases, devices have been developed that mimic the electromagnetic fields that are emitted from people delivering biofield therapies. However, there is limited research examining if humans could potentially inhibit the proliferation of cancer cells and suppress tumor growth through modification of inflammation and the immune system. We found that human NSCLC A549 lung cancer cells exposed to Sean L. Harribance, a purported healer, showed reduced viability and downregulation of pAkt. We further observed that the experimental exposure slowed growth of mouse Lewis lung carcinoma evidenced by significantly smaller tumor volume in the experimental mice (274.3 ± 188.9 mm3) than that of control mice (740.5 ± 460.2 mm3; P < .05). Exposure to the experimental condition markedly reduced tumoral expression of pS6, a cytosolic marker of cell proliferation, by 45% compared with that of the control group. Results of reversed phase proteomic array suggested that the experimental exposure downregulated the PD-L1 expression in the tumor tissues. Similarly, the serum levels of cytokines, especially MCP-1, were significantly reduced in the experimental group (P < .05). Furthermore, TILs profiling showed that CD8+/CD4 immune cell population was increased by almost 2-fold in the experimental condition whereas the number of intratumoral CD25+/CD4+ (T-reg cells) and CD68+ macrophages were 84% and 33%, respectively, lower than that of the control group. Together, these findings suggest that exposure to purported biofields from a human is capable of suppressing tumor growth, which might be in part mediated through modification of the tumor microenvironment, immune function, and anti-inflammatory activity in our mouse lung tumor model."
https://journals.sagepub.com/doi/full/10.1177/1534735419840797

Tuesday, April 2, 2019

Weak Magnetic Fields Manipulate Regeneration in Worms

At magnetic field intensities somewhat above that of Earth, stem cell proliferation shifts gears.

Exposure to weak magnetic fields can, depending on their strength, either slow or boost flatworm regeneration, according to a report in Science Advances today (January 30). The study provides evidence for a possible mechanism, showing that magnetic fields affect the production of reactive oxygen species, which in turn alter cell behavior.
“It’s a very nice paper because they are really trying to dig down into the effects of [magnetic fields],” says biophysicist Thorsten Ritz of the University of California, Irvine, who was not involved in the study. “They are not just adding to the zoo of effects that have been seen [before].”
Furthermore, “it provides the prospect that a weak magnetic field could be employed as a therapeutic tool to non-invasively regulate tissue formation,” says Daniel Kattnig, a biophysicist at the University of Exeter in the UK who also did not participate in the research.