Ozone Sauna Therapy combined with PEMF

 

Conclusions: This pilot study suggests that a combination of OST and PEMF using the HOCATT machine could potentially represent potential therapeutic adjuncts for women with inflammatory disorders such as endometriosis. 

Link to Abstract

A new high-throughput device that measures the electrical properties of cancer cells through continuous flow electrorotation

 From Tokyo:

The electrical properties of cancer cells can provide information on their cancer type, state, and drug resistance. However, conventional platforms to measure these properties are complex and can only analyze a few cells. Researchers have successfully developed a high-throughput device that measures the electrical properties of cancer cells through continuous flow electrorotation. The new platform offers a high degree of automation and can simultaneously analyze several cells.

Link to article

Tumor-destroying sound waves receive FDA approval for liver treatment in humans

 The U.S. Food and Drug Administration has approved the use of sound waves to break down tumors—a technique called histotripsy—in humans for liver treatment.

Pioneered at the University of Michigan, histotripsy offers a promising alternative to cancer treatments such as surgery, radiation and chemotherapy, which often have significant side effects. Today, FDA officials awarded clearance to HistoSonics, a company co-founded in 2009 by U-M engineers and doctors for the use of histotripsy to destroy targeted liver tissue.

A human trial underway since 2021 at the U-M Rogel Cancer Center and other locations has treated patients with primary and metastatic liver tumors via histotripsy, demonstrating the technology’s ability to meet the testing’s primary effectiveness and safety targets.

Link to article

Optimization of tumor-treating field therapy for triple-negative breast cancer cells in vitro via frequency modulation

 Currently, tumor-treating field (TTField) therapy utilizes a single “optimal” frequency of electric fields to achieve maximal cell death in a targeted population of cells. However, because of differences in cell size, shape, and ploidy during mitosis, optimal electric field characteristics for universal maximal cell death may not exist. This study investigated the anti-mitotic effects of modulating electric field frequency as opposed to utilizing uniform electric fields.

Link to paper

New patented PEMF device

 This unit introduces a spectrum of frequencies all at once, a departure from traditional methods that apply one frequency at a time. 

$3+k

Link to company website

Magazine Article

Clinically used osteogenic PEMF signals moderately suppressed cancer cell growth and proliferation both in vitro and in vivo.

 Introduction: Although there have been significant advances in research and treatments over the past decades, cancer remains a leading cause of morbidity and mortality, mostly due to resistance to standard therapies. Pulsed electromagnetic field (PEMF), a newly emerged therapeutic strategy, has been highly regarded as less invasive and almost safe to patients, is now a clinically accepted form to treat diseases including cancer. Breast and lung cancer are the most prevalent forms of human cancers, yet reported investigations on exploring regimes including PEMF are limited. Methods: Intended to examine the anti-tumor effects of a clinically accepted osteogenic PEMF and the possibility of including PEMF in breast and lung cancer treatments, we studied the effects of 2 PEMF signals (PMF1 and PMF2) on breast and lung cancer cell growth and proliferation, as well as the possible underline mechanisms in vitro and in vivo. Results: We found that both signals caused modest but significant growth inhibition (∼5%) in MCF-7 and A549 cancer cells. Interestingly, mice xenograft tumors with A549 cells treated by PEMF were smaller in sizes than controls. However, for mice with MCF-7 tumor implants, treatment with PMF1 resulted in a slight increase (2.8%) in mean tumor size, while PMF2 treated tumors showed a 9% reduction in average size. Furthermore, PEMF increased caspase 3/7 expression levels and percentage of annexin stained cells, indicating the induction of apoptosis. It also increased G0 by 8.5%, caused changes in the expression of genes associated with cell growth suppression, DNA damage, cell cycle arrest, and apoptosis. When cancer cells or xenograft tumors treated with combined PEMF and chemotherapy drugs, PEMF showed growth inhibition effect independent of cisplatin in A549 cells, but with added effect by pemetrexed for the inhibition of MCF-7 growth. Conclusion: Together, our data suggested that clinically used osteogenic PEMF signals moderately suppressed cancer cell growth and proliferation both in vitro and in vivo.

 Article

Quantum biological electron tunnelling

 Researchers have discovered a new way to target and kill cancer cells in hard-to-treat brain tumours using electrically charged molecules to trigger self-destruction, that could be developed into a spray treatment used during surgery.

Link to article

NovaCure Tumor Treating Field Phase III LUNAR trial in non-small cell lung cancer, leading to significant and clinically meaningful improvements in OS when used in conjunction with standard of care.

Although their recent Phase III Ovarian cancer trail failed,  the Phase III LUNAR trial in non-small cell lung cancer, leading to significant and clinically meaningful improvements in OS when used in conjunction with standard of care.

Link to article 

Previously unknown intercellular electricity may power biology

 Researchers have discovered that the electrical fields and activity that exist through a cell's membrane also exist within and around another type of cellular structure called biological condensates. Like oil droplets floating in water, these structures exist because of differences in density. Their foundational discovery could change the way researchers think about biological chemistry. 

Link to article

Pulsed Electricity to control Blood Sugar

 

New treatment may eliminate need for insulin in people with Type 2 diabetes

Link to article

Electricity can heal even the worst kind of wounds three times faster, new study finds

 The researchers noticed that electricity enabled the former to heal three times faster than the latter. “We were able to show that the old hypothesis about electric stimulation can be used to make wounds heal significantly faster,” said Asplund.

According to the study authors, an electric field act as a guide to skin cells. In the absence of current, the cells move randomly, and therefore, the process of healing is slow. However, when cells are electrically stimulated, they all align in one direction and migrate fast toward the damaged site, eventually making a wound heal more quickly. 

Moreover, no side effects were noticed on the cultured wounded cells due to the electric stimulation.

Article

Light-induced acceleration of intracellular delivery

 Researchers have used 100 seconds of laser irradiation to generate convection currents that selectively accelerate biochemical reactions -- due to the photothermal effect -- by concentrating biofunctional molecules at the cell surface. Using this method, useful molecules can be transported into cells at concentrations a hundred to a thousand times lower than with conventional methods. Furthermore, they also succeeded in selectively introducing small molecules into intracellular organelles usually impossible at low concentrations (hundreds of pmol/L) as well as inducing cell death in targeted cells by concentrating anticancer active peptides into them at concentrations so low that they would not be conventionally effective (several tens of nmol/L).

Article: https://www.sciencedaily.com/releases/2023/03/230306101438.htm