Wednesday, March 14, 2018

Pulsed electromagnetic field with Temozolomide can elicit an epigenetic pro-Apoptotic effect on Glioblastoma T98G Cells

Treatment with pulsed electromagnetic fields (PEMFs) is emerging as an interesting therapeutic option for patients with cancer. The literature has demonstrated that low-frequency/low-energy electromagnetic fields do not cause predictable effects on DNA; however, they can epigenetically act on gene expression. The aim of the present work was to study a possible epigenetic effect of a PEMF, mediated by miRNAs, on a human glioblastoma cell line (T98G). We tested a PEMF (maximum magnetic induction, 2 mT; frequency, 75 Hz) that has been demonstrated to induce autophagy in glioblastoma cells. In particular, we studied the effect of PEMF on the expression of genes involved in cancer progression and a promising synergistic effect with temozolomide, a frequently used drug to treat glioblastoma multiforme. We found that electromagnetic stimulation in combination with temozolomide can elicit an epigenetic pro-Apoptotic effect in the chemo-and radioresistant T98G glioblastoma cell line.
https://moh-it.pure.elsevier.com/en/publications/pulsed-electromagnetic-field-with-temozolomide-can-elicit-an-epig

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