Monday, December 31, 2018

On possible role of DNA electrodynamics in chromatin regulation

In spite of extensive research, modeling and predictive ability of gene regulation networks are very limited. This difficulty is likely caused not only by the complexity of gene regulation and but also by an incomplete understanding of gene regulation mechanisms. It is suggested that a major gene regulation mechanism has been missing, the one which is mediated by resonances of electron clouds in chromatin structure. Specifically, polynucleosomal models are proposed for macromolecular electron cloud oscillations in chromatin. It is suggested that these oscillations could be the basis for resonances between polynucleosomal structures in the nucleus. These resonances could serve as a basis for the proposed mechanism of natural gene regulation. Understanding this mechanism would help improving the modeling of gene regulation networks and enable the development of new tools for manipulation of gene expression.
https://www.researchgate.net/publication/322150016_On_possible_role_of_DNA_electrodynamics_in_chromatin_regulation

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