Monday, November 5, 2018

Which eigenfrequencies of non-thermalelectromagnetic waves are life-sustaining and which are, incontrast, detrimental for living cells

Very in-depth paper from Russia and the Netherlands, which explains DNA folding, including a reference to several articles such as:

"Recently, a bio-soliton model was proposed (Geesink and Meijer,2016b), that predicts which eigenfrequencies of non-thermalelectromagnetic waves are life-sustaining and which are, incontrast, detrimental for living cells.

The particular effects are exerted by a range of electromagnetic wave eigen-frequencies of one-tenth of a Hertz till Peta Hertz, that show a pattern of twelve bands, and can be positioned on an acoustic frequency scale. "

Excerpt from the paper's conclusion remark:

"It is shown in the present review that bio-molecular folding and a much wider class of biochemical reactions requires an unrealistically large number of steps to find the correct functional state,irrespective of the various models developed.

The reduction of these issues to some classical problems is considered. On this basis,the known folding-reaction paradox was reformulated and generalized by us. The essence of the generalized paradox, that is, in the proposed broader context, lies in the very fact that complex molecules must reach their native configurations (including their related reactions) during an exponentially large time, which clearly contradicts the observed experimental data on folding time.

In our opinion, perspectives for solving the paradox are associated with an explicit incorporation of topology in the physical models of folding. This condition can be achieved, in our view,through the construction of hybrid models based on the geometrical and physical approaches.

We argue that it is crucial in this respect, to approach the item of protein folding from a holistic standpoint, in which all the inter-acting factors and intrinsic conditions of the intact cell should betaken into account (see Table 3).

These include long-range force fields and local cell biological conditions such as structured water complexes, among many other factors. In particular, there is abundant information in literature on the role of soliton waves(phonon/electron quasi particles) that can be instrumental as guiding elements in the various steps in the folding process"

https://www.researchgate.net/publication/320010451_On_a_generalized_Levinthal%27s_paradox_The_role_of_long-_and_short_range_interactions_in_complex_bio-molecular_reactions_including_protein_and_DNA_folding


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