Magnetic fields and immune response modulation

The effects of extremely low frequency magnetic fields (ELF MF) on biological systems have been studied for decades with focus on possible health risks. Many experimental studies reported various biological effects of exposure to ELF MF, however the biological relevance for these effects is unclear and a convincing evidence for mechanistic explanation is still missing. Nevertheless the modulation of oxidative response after ELF MF exposure has often been described and the release of reactive oxygen species (ROS) or other relevant effects were reported (Simkó, 2004, Simkó & Mattsson, 2004, Simkó, 2007, Mattsson & Simko, 2014). These effects are on a relatively low level (around 30-60 %). At low level “oxidative responses”, ROS can act as second messengers and activate signaling cascades, which in turn can lead to physiological responses such as gene expression, metabolic changes, cell proliferation etc., which subsequently can lead to “cell activation”. Immune-relevant cells use the reactive potential of ROS also to fulfill important physiological functions such as regulating the vascular tone and the cell functions controlled by oxygen concentration but also to activate the immune system functions. The aim of this part of the Action is to focus on possible beneficial effects related to oxidative responses and modulation of immune system functions of ELF MF in order to 1) provide a better understanding of underlying physical and biological mode of action and 2) to contribute to the development of innovative EMF-based medical treatment.
 http://cost-emf-med.eu/wp-content/uploads/2015/01/WM-prop-Myrtill-Simko-Mats-Olof-Mattsson-ELF-magnetic-fields-and-immune-response-modulation.pdf