Wednesday, April 25, 2018

The likely source of magnetosensitivity in photolyase repair: the pyrimidine dimer

This exhaustive article is exciting, regarding DNA repair (cpd repair reaction in particular):

These results clearly illustrate that the CPD reaction is sensitive to low magnetic field strengths and field direction. These data are reminiscent of experiments carried out by N. J. Turro, who established conditions critical for observation of reactions controlled by weak magnetic fields.(11) What is required is a competition between two processes: one that is magnetic field dependent and one that is magnetic field independent. Figure 5 illustrates the CPD repair reaction carried out by photolyase.(12) Here radical pair formation followed by electron transfer leads either to separation of the two repaired thymines or to futile back electron transfer without repair. Thus, the magnetic field dependent radical pair affects the efficiency of the subsequent bond-breaking repair reaction.

https://pubs.acs.org/doi/full/10.1021/acscentsci.8b00008

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