The biological effects of high-gradient magnetic
fields (HGMFs) have steadily gained the increased attention of researchers from
different disciplines, such as cell biology, cell therapy, targeted stem cell
delivery and nanomedicine. We present a theoretical framework towards a
fundamental understanding of the effects of HGMFs on intracellular processes,
highlighting new directions for the study of living cell machinery: changing
the probability of ion-channel on/off switching events by membrane magneto-mechanical
stress, suppression of cell growth by magnetic pressure, magnetically induced
cell division and cell reprograming, and forced migration of membrane receptor
proteins. By deriving a generalized form for the Nernst equation, we find that
a relatively small magnetic field (approximately 1 T) with a large gradient (up
to 1 GT/m) can significantly change the membrane potential of the cell and thus
have a significant impact on not only the properties and biological
functionality of cells but also cell fate
http://www.nature.com/articles/srep37407
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