I asked ChatGPT how Electromagnetic fields treat cancer here's the response

 The use of electromagnetic waves, particularly in the form of Tumor Treating Fields (TTFields), as a treatment for cancer has been a topic of research for over a century. TTFields are a type of therapy that uses low-intensity, alternating electric fields to disrupt the division of cancer cells. Novocure's device, Optune, is an FDA-approved TTFields therapy for certain types of cancer, including glioblastoma and mesothelioma. The underlying science and theory behind why TTFields work are based on several key principles:

Mechanism of Action

Disruption of Mitosis:

Cancer cells are known for their rapid and uncontrolled division. During cell division (mitosis), cells undergo a series of steps to replicate their DNA and divide into two new cells.

TTFields target cells during mitosis, specifically during the metaphase and anaphase stages when the chromosomes are being separated.

The alternating electric fields interfere with the proper alignment and separation of the chromosomes, leading to mitotic disruption. This can result in cell cycle arrest, apoptosis (programmed cell death), or the formation of abnormal cells that cannot survive.

Electrophysical Properties of Cells:

Cancer cells have distinct electrophysical properties compared to normal cells. They are more susceptible to the effects of electric fields due to their high mitotic activity and specific electrical characteristics.

TTFields are designed to exploit these differences, selectively targeting cancer cells while sparing most normal cells.

Microtubule Disruption:

Microtubules are essential components of the cell's cytoskeleton and play a critical role in the separation of chromosomes during cell division.

TTFields can interfere with the polymerization and depolymerization of microtubules, further hampering the mitotic process and leading to cell death.

Clinical Evidence

Glioblastoma:

Optune has been shown to improve survival rates and progression-free survival in patients with glioblastoma, an aggressive type of brain cancer.

Clinical trials have demonstrated that when used in combination with standard treatments like chemotherapy, TTFields significantly extend the overall survival of patients.

Mesothelioma:

The FDA also approved Optune for use in patients with malignant pleural mesothelioma, based on clinical evidence showing improved survival rates when used alongside standard treatments.

Safety and Side Effects

TTFields therapy is generally well-tolerated with a favorable safety profile. The most common side effects are skin irritation and mild discomfort at the site where the electrodes are placed on the scalp.

Because TTFields are non-invasive and targeted, they do not carry the systemic side effects typically associated with conventional cancer treatments like chemotherapy and radiation therapy.

Ongoing Research

Research continues to explore the efficacy of TTFields in other types of cancer and to optimize the delivery and effectiveness of the therapy.

Studies are also investigating the combination of TTFields with other emerging cancer treatments, such as immunotherapy and targeted therapies.

In summary, TTFields therapy works by exploiting the unique electrical properties and mitotic behavior of cancer cells to disrupt their division and induce cell death. Novocure's Optune device represents a significant advancement in the non-invasive treatment of certain aggressive cancers, offering patients a new therapeutic option that complements existing treatments.

Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma

 We conclude that noninvasive RFR exposure induces antitumor remodeling of the TIME, leading to inhibition of tumor progression, which provides a promising novel strategy for TIME priming and potential combination with cancer immunotherapy.

Link to publication

Pulsed Electromagnetic Fields (PEMFs) Trigger Cell Death and Senescence in Cancer Cells

 Abstract

The currently available anti-cancer therapies, such as gamma-radiation and chemotherapeutic agents, induce cell death and cellular senescence not only in cancer cells but also in the adjacent normal tissue. New anti-tumor approaches focus on limiting the side effects on normal cells. In this frame, the potential anti-tumor properties of Pulsed Electromagnetic Fields (PEMFs) through the irradiation of breast cancer epithelial cells (MCF-7 and MDA-MB-231) and normal fibroblasts (FF95) were investigated. PEMFs had a frequency of 8 Hz, full-square wave type and magnetic flux density of 0.011 T and were applied twice daily for 5 days. The data collected showcase that PEMF application decreases the proliferation rate and viability of breast cancer cells while having the opposite effect on normal fibroblasts. Moreover, PEMF irradiation induces cell death and cellular senescence only in breast cancer cells without any effect in the non-cancerous cells. These findings suggest PEMF irradiation as a novel, non-invasive anti-cancer strategy that, when combined with senolytic drugs, may eliminate both cancer and the remaining senescent cells, while simultaneously avoiding the side effects of the current treatments.

Link to publication

Density Based Characterization of Mechanical Cues on Cancer Cells Using Magnetic Levitation

 How interesting:

A magnetic levitation device is developed (i.e., MagDense platform) where cells are levitated in a magnetic gradient allowing them to equilibrate to a levitation height that corresponds to their unique cellular density. In application of this system, MDA-MB-231 breast and A549 lung cancer cells are cultured and overall differences in cell density are observed in response to increasing collagen fiber density. 

Link to paper

Red light therapy improves glucose metabolism

 You may wonder why I post an article about light therapy, it's because light is another form of electromagnetism:

The red light can penetrate through the skin and positively impact the mitochondria within the body’s cells, helping to create more energy and allowing the cells to function better and repair themselves.

Co-lead study author Dr. Michael Powner, senior lecturer in neurobiology in the School of Health & Psychological Sciences at City University London said they decided to look at red light therapy as a way to help control blood sugar levels after reading a study from 2019Trusted Source highlighting that sunlight exposure could correlate with improved glucose metabolism.

“We explored this in bumblebees nd found that red light reduced systemic glucose after feeding,” Dr. Powner told Medical News Today. “This latest study clearly shows a translation of this to humans.”

“Red light is absorbed by mitochondria and helps them produce more energy,” he explained.

“It lubricates the energy-making machine. But in producing more energy this way they need more raw material and this is largely glucose. They take this out of the blood.”

Link to article

Related, see also

Infoceuticals and imprinting may exert positive biological effects on cellular physiology.

 Abstract:

Living organisms, from the simplest organization to the more complex, all share the requirement

of energy in order to perform basic functions that sustain life and ensure its continuity. Cellular

physiology requires complex mechanisms to maintain homeostasis that are activated when

normal parameters change. Ancient medical practices like acupuncture suggest that many of the

human health impairments occur because of an energetic imbalance. In this regard, NES Health

has developed the concept of "Infoceuticals" -- remedies designed to restore the body's energetic

balance, or the means by which it is powered and communicates wirelessly. These remedies may

be administered through a special preparation of mineralized water ("imprinted" with photons

and magnetic fields), or imprinted directly into the body via electronic equipment. In this report,

we used a multicellular platform to determine the effect on cellular physiology of diverse

Infoceuticals both in liquid form and through direct imprinting. We observed unique and cellspecific effects in terms of cellular membrane structure, mitochondrial function, oxidative stress,

and viral infection protection. These findings aim to provide basic science insights to the process

of understanding the underlying phenomena that take place after Infoceutical treatments.

Link to paper

Stanford School of Medicine Tumor Treating Fields

 ROOT, Switzerland–(BUSINESS WIRE)– Novocure (NASDAQ: NVCR) today announced it has entered into an agreement with Stanford University to establish the Stanford School of Medicine Tumor Treating Fields (TTFields) Research Program. The program is intended to support both preclinical studies and clinical trials with TTFields, electric fields that exert physical forces to kill cancer cells via a variety of mechanisms.

Link to Press Release

Ozone Sauna Therapy combined with PEMF

 

Conclusions: This pilot study suggests that a combination of OST and PEMF using the HOCATT machine could potentially represent potential therapeutic adjuncts for women with inflammatory disorders such as endometriosis. 

Link to Abstract

A new high-throughput device that measures the electrical properties of cancer cells through continuous flow electrorotation

 From Tokyo:

The electrical properties of cancer cells can provide information on their cancer type, state, and drug resistance. However, conventional platforms to measure these properties are complex and can only analyze a few cells. Researchers have successfully developed a high-throughput device that measures the electrical properties of cancer cells through continuous flow electrorotation. The new platform offers a high degree of automation and can simultaneously analyze several cells.

Link to article

Tumor-destroying sound waves receive FDA approval for liver treatment in humans

 The U.S. Food and Drug Administration has approved the use of sound waves to break down tumors—a technique called histotripsy—in humans for liver treatment.

Pioneered at the University of Michigan, histotripsy offers a promising alternative to cancer treatments such as surgery, radiation and chemotherapy, which often have significant side effects. Today, FDA officials awarded clearance to HistoSonics, a company co-founded in 2009 by U-M engineers and doctors for the use of histotripsy to destroy targeted liver tissue.

A human trial underway since 2021 at the U-M Rogel Cancer Center and other locations has treated patients with primary and metastatic liver tumors via histotripsy, demonstrating the technology’s ability to meet the testing’s primary effectiveness and safety targets.

Link to article

Optimization of tumor-treating field therapy for triple-negative breast cancer cells in vitro via frequency modulation

 Currently, tumor-treating field (TTField) therapy utilizes a single “optimal” frequency of electric fields to achieve maximal cell death in a targeted population of cells. However, because of differences in cell size, shape, and ploidy during mitosis, optimal electric field characteristics for universal maximal cell death may not exist. This study investigated the anti-mitotic effects of modulating electric field frequency as opposed to utilizing uniform electric fields.

Link to paper

New patented PEMF device

 This unit introduces a spectrum of frequencies all at once, a departure from traditional methods that apply one frequency at a time. 

$3+k

Link to company website

Magazine Article

Clinically used osteogenic PEMF signals moderately suppressed cancer cell growth and proliferation both in vitro and in vivo.

 Introduction: Although there have been significant advances in research and treatments over the past decades, cancer remains a leading cause of morbidity and mortality, mostly due to resistance to standard therapies. Pulsed electromagnetic field (PEMF), a newly emerged therapeutic strategy, has been highly regarded as less invasive and almost safe to patients, is now a clinically accepted form to treat diseases including cancer. Breast and lung cancer are the most prevalent forms of human cancers, yet reported investigations on exploring regimes including PEMF are limited. Methods: Intended to examine the anti-tumor effects of a clinically accepted osteogenic PEMF and the possibility of including PEMF in breast and lung cancer treatments, we studied the effects of 2 PEMF signals (PMF1 and PMF2) on breast and lung cancer cell growth and proliferation, as well as the possible underline mechanisms in vitro and in vivo. Results: We found that both signals caused modest but significant growth inhibition (∼5%) in MCF-7 and A549 cancer cells. Interestingly, mice xenograft tumors with A549 cells treated by PEMF were smaller in sizes than controls. However, for mice with MCF-7 tumor implants, treatment with PMF1 resulted in a slight increase (2.8%) in mean tumor size, while PMF2 treated tumors showed a 9% reduction in average size. Furthermore, PEMF increased caspase 3/7 expression levels and percentage of annexin stained cells, indicating the induction of apoptosis. It also increased G0 by 8.5%, caused changes in the expression of genes associated with cell growth suppression, DNA damage, cell cycle arrest, and apoptosis. When cancer cells or xenograft tumors treated with combined PEMF and chemotherapy drugs, PEMF showed growth inhibition effect independent of cisplatin in A549 cells, but with added effect by pemetrexed for the inhibition of MCF-7 growth. Conclusion: Together, our data suggested that clinically used osteogenic PEMF signals moderately suppressed cancer cell growth and proliferation both in vitro and in vivo.

 Article

Quantum biological electron tunnelling

 Researchers have discovered a new way to target and kill cancer cells in hard-to-treat brain tumours using electrically charged molecules to trigger self-destruction, that could be developed into a spray treatment used during surgery.

Link to article

NovaCure Tumor Treating Field Phase III LUNAR trial in non-small cell lung cancer, leading to significant and clinically meaningful improvements in OS when used in conjunction with standard of care.

Although their recent Phase III Ovarian cancer trail failed,  the Phase III LUNAR trial in non-small cell lung cancer, leading to significant and clinically meaningful improvements in OS when used in conjunction with standard of care.

Link to article 

Previously unknown intercellular electricity may power biology

 Researchers have discovered that the electrical fields and activity that exist through a cell's membrane also exist within and around another type of cellular structure called biological condensates. Like oil droplets floating in water, these structures exist because of differences in density. Their foundational discovery could change the way researchers think about biological chemistry. 

Link to article

Pulsed Electricity to control Blood Sugar

 

New treatment may eliminate need for insulin in people with Type 2 diabetes

Link to article

Electricity can heal even the worst kind of wounds three times faster, new study finds

 The researchers noticed that electricity enabled the former to heal three times faster than the latter. “We were able to show that the old hypothesis about electric stimulation can be used to make wounds heal significantly faster,” said Asplund.

According to the study authors, an electric field act as a guide to skin cells. In the absence of current, the cells move randomly, and therefore, the process of healing is slow. However, when cells are electrically stimulated, they all align in one direction and migrate fast toward the damaged site, eventually making a wound heal more quickly. 

Moreover, no side effects were noticed on the cultured wounded cells due to the electric stimulation.

Article

Light-induced acceleration of intracellular delivery

 Researchers have used 100 seconds of laser irradiation to generate convection currents that selectively accelerate biochemical reactions -- due to the photothermal effect -- by concentrating biofunctional molecules at the cell surface. Using this method, useful molecules can be transported into cells at concentrations a hundred to a thousand times lower than with conventional methods. Furthermore, they also succeeded in selectively introducing small molecules into intracellular organelles usually impossible at low concentrations (hundreds of pmol/L) as well as inducing cell death in targeted cells by concentrating anticancer active peptides into them at concentrations so low that they would not be conventionally effective (several tens of nmol/L).

Article: https://www.sciencedaily.com/releases/2023/03/230306101438.htm

Magnetism of a single atom’s nucleus

 IBM Research article I found, very interesting:

Research Article

The reason I researched this subject, was due to a crop circle I viewed on http://www.cropcircleconnector.com/: